Letrozole belongs to the group of drugs used in hormone therapy, belongs to the group of hormone antagonists, enzyme inhibitors. The effect of the application is due to the properties of its main active ingredient, letrozole. Letrozole is a highly specific non-steroidal inhibitor of aromatase activity, which also has the property of inhibiting estrogen biosynthesis. Thus, letrozole produces an antitumor effect in cases where the tumor is estrogen-dependent. You can buy letrozole online without prescription in our online pharmacy. Just click link below:
This drug is used for adjuvant therapy of hormone-positive breast cancer in the early stages of women who are in the postmenopausal period.
It is also used in neoadjuvant therapy in postmenopausal women with localized hormone-positive breast cancer, which provides an opportunity for further surgical treatment of women who have not been shown surgical treatment prior to therapy with letrozole. Subsequent treatment after surgery should comply with the accepted standard for the postoperative period.
It does not apply if the patient has an increased sensitivity (allergy) with respect to one of the components that are part of the preparation. Also contraindicated in: - endocrine status characteristic of the premenopausal period; - severe liver failure; - preoperative use of the drug, if the status of receptors is negative or unknown. Not applicable for women of reproductive age. Not applicable in pediatrics.
Treatment of pregnant women with this drug is contraindicated. In the treatment of lactation should be suspended.
This drug is taken at a dosage of 2.5 mg (1 tablet of the drug Letrozol), 1 time per day. Duration of treatment: - 5 years or before the onset of relapse - with adjuvant and extended adjuvant therapy; - until the obvious progress of the disease - in patients with metastases. In the course of treatment, regular course of the disease should be carried out in order to notice in time the possible progress of the disease. Elderly, mild and moderate liver and kidney disorders do not require correction of the treatment regimen.
Possible side effects such as: - neoplasms of the urogenital system, including cysts and polyps, pain in the tumor foci (only with metastatic lesions); - leukopenia, thrombocytopenia; - angioedema, anaphylactic reactions; - anorexia, changes in appetite, body weight, increased blood cholesterol levels, edema; - depression, anxiety, nervousness, irritability; - headache, dizziness, drowsiness, insomnia, memory impairment, dysesthesia, paresthesia, hypostezia, a violation of taste, stroke; - cataract, retinal thrombosis, retinal detachment; - palpitations, tachycardia; - thrombophlebitis, arterial hypertension, cases of cardiac ischemia; - pulmonary embolism, arterial thrombosis, cerebrovascular infarction, pulmonary hypertension, stroke, arrhythmia, pericarditis; - Angina pectoris, myocardial infarction, heart failure; - shortness of breath, cough, interstitial lung disease; - stomatitis, dry mouth; - hepatitis; - alopecia, excessive sweating, rash, allergic urticaria, toxic epidermal necrolysis, erythema multiforme; - arthralgia, muscle pain, bone pain, osteoporosis, bone fractures, arthritis; - vaginal bleeding, pain in the mammary glands; - hot flashes, asthenia, peripheral edema, fever, thirst.
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