Genital, or genital herpes is a genital disease caused by herpes simplex viruses (HSV or Herpes simplex virus, HSV). Now we know buy valtrex over the counter of eight types of the herpes virus, of which genital herpes valacyclovir 500 mg cause the first 2 types (HSV-1 and HSV-2). In 80% of cases, genital herpes is caused by HSV-2, in 20% - by HSV-1 or by a combination of them. The first type of virus often causes the very first episode of genital herpes valtrex cost without prescription. Repeated manifestations of genital herpes are almost always associated with HSV-2. Genital herpes usually affects the external genitalia, crotch and anus, and (rarely) the vagina and cervix (vaginal and cervical herpes valtrex price online). In severe cases, the infection can pass to the body of the uterus and its appendages buy valtrex over the counter (fallopian tubes and ovaries) valacyclovir price cheap. Valacyclovir over the counter.
Herpes simplex viruses 1 and 2 types infected up to 90% of the adult population of the Earth. After infection, the herpes simplex virus enters the nerve nodes located near the spinal cord and remains in them for life. However, manifestations of genital herpes valacyclovir 500 mg appear only in a small part of infected people valtrex price cheap. In the United States, 3% of the population buy valacyclovir online reported having genital herpes episodes at least once in their life, but the analysis showed that more than 20% of the population is infected with HSV-2. The total transmission frequency of herpes valtrex cost during pregnancy is 2 per 100,000 births (data for Europe) valtrex without prescription.
The main way of transmission of genital herpes is sexual. Herpes virus is transmitted both at usual genital contacts (usually HSV-2), and at oral (VPG-1) and anal sex (HSV-2). Infection is possible in the absence of a sexual partner of any manifestations of the disease in more than 50% of cases. The household way of infection (for example valacyclovir 500 mg price, through personal hygiene items) with genital herpes is rare valtrex without a prescription. The probability of infection is higher if there are manifestations of herpes or skin and mucous membrane damage (wounds, cracks) valtrex for sale. The total probability of contracting an infected male partner for a woman is about 17%. Using valtrex otc a condom reduces this probability by almost 2 times.
Genital herpes is more often affected by people buy valtrex online overnight exposed to one or more of the following risk factors:
The main manifestations of genital herpes are:
These signs appear only with exacerbations of genital herpes, which last usually 1-2 weeks. Throughout the rest of the time, there are no manifestations of infection. Antiviral drug, L-valine ester of acyclovir, which is a synthetic analogue of a purine nucleoside-guanine. In the human body valtrex cost, valacyclovir 500 mg is rapidly and almost completely converted to acyclovir and valine, probably involving hydrolases. Acyclovir over the counter valtrex selectively inhibits herpes viruses valacyclovir 1 gram by influencing in vitro herpes simplex viruses (HSV) of the first and second types, varicella and herpes zoster viruses, cytomegalovirus (CMV), the Epstein-Barr virus (EBV) and the human herpes virus type 6 (HHV-6). After phosphorylation into the active form - acyclovir triphosphate buy valtrex without prescription - inhibits the synthesis of the DNA of the herpes virus. The first stage of phosphorylation requires the activity of an enzyme specific for the virus; The need for activation of acyclovir is largely due to the selectivity of the drug. Further phosphorylation and the formation of triphosphate are carried out with the help of cellular kinases valtrex price online. Acyclovir triphosphate is a competitive inhibitor of viral DNA polymerase, and its incorporation order valtrex online into DNA leads to the completion of chain synthesis, which as a result inhibits the synthesis of viral DNA and the multiplication of the virus. Valaciclovir accelerates buy valacyclovir online the process of disappearance of pain in herpes zoster; Reduces the duration of pain and reduces the percentage of patients to buy valtrex over the counter with normal immunity, who may experience acute or chronic neuralgia, and also reduces the risk of complications with ocular (ophthalmic) herpes zoster valacyclovir 500 mg. After application, it is absorbed orally from the gastrointestinal tract. Cmax valacyclovir price otc in plasma is 4% of the concentration of acyclovir buy valacyclovir, tmax is 30-100 minutes. Bioavailability of acyclovir after taking valaciclovir is 54% and does not change when taking the drug with food. Tmax of acyclovir is 1.5 hours. The pharmacokinetic profiles of valaciclovir and acyclovir are identical both after single-use and after repeated use. Valacyclovir is 15% bound to plasma proteins. T1 / 2 is approximately 3 hours. The drug is excreted from the body with urine, mainly in the form of acyclovir and its metabolite - 9-carboxymethoxy-methylguanine valtrex price pharmacy online.
Infection with the virus of varicella buy valtrex over the counter and shingles (TSV): treatment of shingles and ophthalmological herpes zoster in immunocompetent adults; Treatment of herpes zoster in adults with moderately reduced immunity over the counter valtrex online cheap. Treatment and inhibition of infections of the skin and mucous membranes caused by the herpes simplex virus (HSV), including: treatment of the first signs and recurrence of genital herpes in immunocompetent adults and adolescents, as well as in adults with weakened immunity; Suppression of recurrence of genital herpes in immunocompetent adults and adolescents, as well as adults with weakened immunity; Treatment and prevention of relapses of eye infections. There valacyclovir 1 gm have been no clinical studies involving patients infected with HSV with weakened immunities, except HIV-infected. Prevention of infection with cytomegalovirus (CMV) after organ valacyclovir without prescription transplantation in adults and adolescents valacyclovir 500 mg valtrex cost.
Hypersensitivity to valaciclovir, acyclovir buy valtrex over the counter or any component of the drug. Care should be taken in patients with impaired renal function and modify the dosage; These patients have a higher risk of developing side effects from the nervous system. The probability of renal dysfunction in elderly patients is higher, therefore, for this group of patients, a dose reduction should also be considered. Care should be taken when administering high doses of valaciclovir in parallel with drugs that affect kidney function. It is necessary to remember the proper hydration of patients, especially the elderly. There is no information on the use of the drug by children, and also on the use of doses of valacyclovir price exceeding 4 g / day in patients with liver disease. There valtrex 1000 mg pills have been no studies on the use of the drug by patients after liver transplantation; These patients should be careful, applying doses exceeding 4 g / day. During treatment of herpes zoster should closely monitor the clinical response and consider the use of antiviral therapy, especially in patients with weakened immunity valacyclovir hcl 500 mg and with ophthalmic herpes. If the clinical response to oral treatment is insufficient, intravenous antiviral therapy should be used. Patients with complications, including changes in organs valacyclovir 500 mg, neuropathy, encephalitis and cerebrovascular complications, as well as patients with weakened immunities with ophthalmic herpes or with a high risk of metastasis and organ damage, should be treated with intravenous antiviral therapy. In the case of genital herpes, the patient should be informed of the possibility of contracting a partner and recommend safe sex valtrex cost. Data on the efficacy of valacyclovir, obtained from patients after over the counter valtrex online transplantation with a high risk of CMV, show that valaciclovir can only be used when, for safety reasons, valganciclovir or ganciclovir can not be used. When using high doses of valacyclovir 1 gm, for example, in the prevention of cytomegalovirus infection, side effects (including those from the CNS) can occur more often than when smaller doses are given with other indications, so patients should carefully monitor kidney function and, if necessary, modify Dose can i buy valtrex over the counter.
Caution should be exercised during the parallel use of valaciclovir with nephrotoxic drugs (such as aminoglycosides, platinum organic compounds, iodinated contrast agents, methotrexate, pentamidine, foscarnet, cyclosporin, tacrolimus), especially in patients with renal insufficiency, and, if necessary, Kidney function. Cimetidine buy valtrex over the counter and probenecid used in parallel with valacyclovir price online, due to decreased renal clearance, increase the AUC of acyclovir in the plasma by 25% and 45%, respectively, while at the same time, applied simultaneously, increase the valaciclovir AUC by 65% generic for valtrex cost. Other drugs that inhibit active tubular secretion (including tenofovir), used in parallel with valaciclovir, can increase the plasma concentration of acyclovir buy valtrex over the counter. Similarly, the use of valaciclovir can lead to an increase in plasma concentrations of concomitant drugs. Patients receiving high doses of valaciclovir should be cautioned with the concomitant use of drugs that inhibit active renal tubular secretion. With parallel use of acyclovir and the inactive metabolite of mycophenolate mofetil, an increase in the AUC of these drugs is observed; During studies involving healthy volunteers, after simultaneous application of valaciclovir and myco phenolate mofetil, cmax and AUC did not change get valtrex prescription online. Clinical experience with the simultaneous use of these drugs is limited.
Very often: headache. Often: nausea, dizziness, vomiting, diarrhea, rash, including caused by increased photosensitivity, itching. Not very often: leukopenia (especially in patients with weakened immunity), thrombocytopenia, over the counter valtrex online confusion, hallucinations, disorientation, tremor, excitement, shortness of breath, abdominal discomfort, transient increase in liver function indicators, urticaria, kidney pain (which may be related With renal insufficiency), hematuria generic for valtrex cost. Rarely: anaphylaxis, ataxia, slurred speech, convulsions, encephalopathy, coma, psychotic symptoms, delirium, angioedema, renal dysfunction valacyclovir 500 mg, acute renal failure (especially in elderly patients or in patients with renal insufficiency receiving doses exceeding recommended). In addition, precipitation of acyclovir crystals in the renal tubules was observed. Neurological disorders can be associated with encephalopathy and, as a rule, are temporary and occur mainly in patients with impaired renal function or other predisposing factors. In patients after organ transplantation receiving high doses (8 g / day) for the prevention of CMV, neurological reactions occur more often than with lower doses used for other indications. There have been reports of cases of renal failure, microangiopathic hemolytic anemia, and thrombocytopenia in adult patients with severe immune system diseases (especially in the advanced stage of HIV infection) receiving high doses (8 g / day) of valaciclovir buy valtrex over the counter for a long time. However, these same symptoms were also observed in patients with the same underlying or concomitant diseases who did not receive valaciclovir. Symptoms of valaciclovir overdose (often occur in patients with renal insufficiency or in elderly people who have not adjusted the dosage): acute renal failure, neurologic symptoms (including confusion, hallucinations, arousal, coma), nausea and vomiting. Apply symptomatic treatment. Hemodialysis is an effective way to remove acyclovir.
Category C. The use of valacyclovir in pregnant women should be limited to cases where the potential benefits of treatment exceed the risk to the fetus. Acyclovir penetrates into breast milk. When valacyclovir is used in therapeutic doses during breastfeeding, the dose for the baby should be less than 2% of the intravenous dose of acyclovir used in the treatment of herpes in newborns. During lactation, valacyclovir should be used with extreme caution and only with serious clinical indications.
Orally. Chicken pox and shingles. Adults: 1 g 3 × / day; Patients with normal immunity to apply for 7 days, patients with immunocompromised - at least 7 days plus two days after the transformation of changes in scabs. There is no evidence of efficacy after 72 hours after the onset of symptoms. Patients with impaired immunity are advised to use antiviral therapy in the event that no more than 7 days after the appearance of the vesicles or at any time before the change in the scabs. Treatment and inhibition of infections of the skin and mucous membranes caused by the herpes simplex virus (HSV). Treatment. Adults and adolescents over 12 years of age with normal immunity: 500 mg 2 × / day. Therapy should be started as soon as possible, in the case of recurrent herpes it is best to begin treatment in the prodromal period or after the appearance buy valtrex over the counter of the first signs of skin lesion, the duration of treatment is 3-5 days; In severe primary infections, treatment can be extended up to 10 days. Lip herpes in adults and adolescents: 1 day 2 g 2 × / day; The second dose should be taken no earlier than 6 hours after the first dose; Treatment should begin in the prodromal period. Adults with weakened immunity: 1 g 2 × / day; Treatment should begin within 48 hours after the onset of signs of the disease and continue for at least 5 days, and in the case of primary herpes it is necessary to extend the treatment to 10 days. Prevention of recurrence of herpes simplex. Adults and adolescents over 12 years of age with normal immunity: 500 mg 1 × / day; In patients with frequent relapses of the disease (at least 10 infections a year without treatment), a dose of 250 mg 2 × / day can be effective. Patients with weakened immunity: 500 mg 2 × / day. After 6-12 months, it is necessary to revise the method of treatment. Prevention of cytomegalovirus buy valtrex over the counter (CMV) and cytomegalovirus disease that occurs after organ transplantation. Adults and adolescents over 12 years of age 2 g 4 × / day; Therapy should be started as soon as possible; Treatment usually lasts 90 days, but patients at high risk may need to continue treatment. In patients with renal failure, the dosage depends on the creatinine clearance. Detailed information - see: registered materials of the manufacturer.