Buy Letrozole Online

Generic Femara (letrozole) is an aromatase inhibitor which lowers estrogen levels is post-menopausal women (hormone therapy). This helps to slow breast tumors growth that relies on estrogen to grow. Generic Femara offers highly effective treatment of numerous symptoms, order it today and experience better health.

  • Name: Letrozole (Femara)
  • Dosage: 2.5mg
  • Pack: 30,60,90,180 pills
  • Price: from 1.47 $ Per Pill

Femara 2.5 mg cost over the counter

Buy letrozole online is a competitive non-steroidal aromatase inhibitor. Aromatase is an enzyme that ensures the conversion of androgens (synthesized in the adrenal glands) into estrone and estradiol in postmenopausal women. Given that in some cases, the growth of tumor tissues depends on the presence of estrogens, which during the postmenopause are mainly formed only with the participation of aromatase, the use of aromatase inhibitors can reduce the level of estrogen and create conditions for tumor response to therapy. In experiments on animals, the use cost of letrozole 2.5 mg price over the counter led to a reduction in uterine mass and regression of tumors (hormone-dependent) with the effectiveness of a similar ovariectomy. In this case, against the background of therapy letrozolom (in contrast to ovariectomy), there is no increase in serum levels of follicle-stimulating hormone. Femara cost selectively inhibits the production of steroids in the gonads, without affecting the production of glucocorticosteroids and mineralocorticosteroids in the adrenal glands. The mechanism of suppression of aromatase is realized due to the competitive binding of letrozole to the cytochrome P450 heme, as a result of which the biosynthesis of estradiol in all tissues of the body decreases.

On the background of buy letrozole online pharmacy therapy there is a decrease in serum levels of estradiol, estrone and estrone sulfate without significant effect on the synthesis of aldosterone and corticoids, as well as thyroid hormones. Letrozole in the digestive tract is absorbed quickly enough. Bioavailability reaches 99.9%, while food slightly reduces the rate of absorption, without having a significant effect on the time to reach peak concentrations.

About 60% of letrozole in the serum is in a bound state (mainly with albumins). The level of letrozole in leukocytes reaches 80% of the plasma level. Metabolized letrozole slightly (about 82% of labeled cost of letrozole 2.5 mg cheap price online in the serum was unchanged), femara cost online derivatives do not have therapeutic activity. Metabolism takes place with the participation of isoenzymes P450. Letrozole is well distributed in tissues, the volume of distribution reaches 1.87 ± 0.47 l / kg. Letrozole is excreted by the kidneys. Half-life time reaches 2 days, equilibrium concentrations with constant intake of therapeutic doses are noted at 2-6 weeks of treatment (equilibrium concentrations are approximately 7 times higher than the concentrations obtained with a single dose of best place to buy letrozole online). However, buy femara online without prescription the values ​​of equilibrium concentrations are 1.5-2 times higher than the expected equilibrium concentrations, which can be calculated by taking into account concentrations after single doses (indicating a deviation from linear pharmacokinetics).

Letrozole does not cumulate in the body (given the long time of maintaining equilibrium concentrations). Indications for use:

  • Letrozole 2.5 mg is used in postmenopausal women in the early stages of estrogen dependent breast cancer (as adjuvant therapy).
  • The drug is used for extended adjuvant treatment in postmenopausal women in the early stages of breast cancer (after a standard course of adjuvant therapy with tamoxifen).
  • Letrozole is used as a first-line therapy choice for localized or metastatic breast cancer (hormone-positive) in postmenopausal women, and in cases where the presence of positive receptors for hormones is unknown.
  • The drug can be used to treat postmenopausal women (whether menopause is natural or caused artificially) with advanced breast cancers in the case of progression of the disease after prior treatment with antiestrogens.

Letrozole cost cheap appoints exclusively the attending physician. Therapy with buy letrozole online without prescription should be controlled by a doctor. Doses and duration of therapy are determined individually and can vary depending on the nature and severity of the disease buy femara online. Usually, adjuvant therapy regimens prescribe a daily dose of letrozole 2.5 mg pills over the counter in the amount of 2.5 mg per day. In this adjuvant and extended adjuvant therapy can last up to 5 years (or until the onset of a relapse of the disease).

After standard tamoxifen therapy, patients should be under the supervision of a physician and continue therapy with femara cost over the counter for 4 years (or until the recurrence of the disease). Patients with metastases of therapy buy letrozole online should be held until the moment when signs of progress of the disease are not obvious. When using letrozole 2.5 mg in preoperative preparation, the doctor must constantly monitor the patient condition. To elderly people and with moderate or weak violations of the liver, a dose change of letrozole is not necessary. Given the risk of developing osteoporosis in the background of treatment with Letrozole price cheap, it is necessary to monitor the condition of bone tissue in patients receiving treatment.

Side Effects

Letrozole cost online, as a preparation of adjuvant therapy femara price for breast cancer, as well as a means of treating early stages of breast cancer (in people who previously received tamoxifen), is well tolerated by patients. Side effects on the background of treatment with letrozole 2.5 mg otc in most cases were due to the deficiency of estrogens, which causes the drug. Side effects are presented on the basis of data from clinical studies and post-licensing control. Undesirable effects from:

  • Blood systems: leukopenia;
  • urinary system: urinary tract infection, frequent urination;
  • Nervous system: anxiety, irritability, nervousness, depressive states, headache, sleep and memory disturbances, dizziness, hypoesthesia and paresthesia. In addition, cerebral blood flow disorders are possible;
  • sensory organs: decreased visual acuity, taste disorder, cataract, eye irritation;
  • heart and blood vessels: tachycardia, hypertension, palpitations, thrombophlebitis, angina pectoris, arterial thrombosis, pulmonary embolism;
  • digestive tract: lability of appetite and body weight, hypercholesterolemia, vomiting and nausea, digestive and stool disorders, abdominal pain, dry mouth, stomatitis and increased activity of liver enzymes;
  • Reproductive system: vaginal discharge, vaginal bleeding femara generic, vaginal dryness, painful sensations in the mammary glands.

Allergic reactions: itching and dryness of the skin, alopecia, hives, sweating, rashes of various types. Other side effects: pain in the tumor site, swelling, coughing, shortness of breath, joint pain, muscle and bones, osteoporosis, increased risk of bone fractures, arthritis. In addition, against the background of therapy with buy letrozole online, tides, fatigue, fever and thirst can develop.

Contraindications

  • Intolerance to letrozole price or substances that are used to create tablets.
  • Endocrine status, which is typical for premenopause.
  • Severe forms of liver failure (class C on the Child-Pugh scale).

Femara 2.5 mg is not used in preoperative therapy in cases where the status of receptors is unknown or is defined as negative. Tablets buy letrozole online is not used in pediatrics. Caution should be exercised in cases where letrozole 2.5 mg therapy is needed in women with end-stage renal failure (in such patients, femara cost was not tested and the drug can only be prescribed after a thorough analysis of the risks and benefits). It is recommended to exclude the management of unsafe mechanisms during therapy with Letrozole (given its possible undesirable effects on the nervous system).

Pregnancy

Femara 2.5 mg is strictly prohibited for use in the therapy of women bearing a child or nursing a baby.

Drug Interactions

Experience with the drug letrozole cost with other antitumor drugs is not. In vitro, cimetidine and warfarin had no effect on the efficacy and plasma concentrations of letrozole (despite the significant effects of cimetidine and warfarin on P450). Significant interactions letrozola with benzodiazepines, anti-inflammatory drugs, furosemide, barbiturates and omeprazole were not observed. In vitro letrozole leads to inhibition of the activity of CYP2 A6 and CYP2 C19, however, no clinically significant interaction with diazepam (substrate CYP2 C19) was noted. Despite the fact that the probability of interactions letrozola with the isoenzyme CYP2 C19 is negligible, caution should be exercised when combined with the appointment of buy letrozole online with substances metabolized with the participation of CYP2 C19.

Overdose

Clinical experience of dozesol overdose is absent. Animal studies indicate a low risk of acute intoxication with letrozole. In clinical trials, there is the experience of a single dose of 30 mg letrozole and long-term therapy with letrozole at a dose of 5 mg / day, which were not accompanied by the development of serious side effects and effects that were potentially lethal. There is no specific antidote for buy letrozole online. In acute overdose, standard clinical measures recommended for intoxication with drugs are carried out.

Form of issue

Tablets in the shell Letrozol, packaged in blister plates. In a pack of 30 tablets (3 blisters for 10 tablets).

Storage conditions

Letrozole should be stored in places that are out of the reach of children. The shelf life of tablets is 2 years. Specific temperature storage conditions are not required. The preparation letrozole cost must be protected from direct sunlight.

Aromatase inhibitors

Aromatase (AI) inhibitors belong to the group of medicines used in the treatment of cancer caused by the sensitivity of the tumor to estradiol (most often it is breast cancer); The essence of the work of the drugs of this group is reduced to the blocking of the work of the aromatase enzyme, which is involved in the modification of androgen hormones into estrogens. IAs are popular in sports because of the ability to reduce the level of female sex hormones due to high levels of consumption of steroids subject to enzyme conversion by aromatase (under its influence, testosterone is converted to estradiol and androstenedione, subsequently androstenedione is transformed into estrone, but estrone for its biological activity in 5 Times less active than estradiol, and therefore it is not considered an active participant in the side effects of estrogen in aromatization); Also, IAs are used to combat the effects of high levels of estrogen, such as the fight against gynecomastia (growth of breast glands by female type) or its prevention, in rare cases, the consumption of inhibitors is directed to increase levels of LH and FSH, which leads to an increase in the level of endogenous testosterone That is for post-course therapy). In BB, aromatase inhibitors are consumed during the cycle of anabolic steroids in order to:

  • 1. Prevention of gynecomastia (an excessive level of estradiol and estrone due to the aromatization of steroids under the influence of aromatase can potentially lead to the growth of mammary glands in the athlete by female type, thus the intake of IA will allow to block aromatase, as a key enzyme participating in the direct growth of estradiol level).
  • 2. Getting rid of excess water (as is known with an increased level of estrogen, the accumulation of water increases, this is because estradiol is able to regulate the balance of sodium in cells and raising the level of sodium entails the accumulation of excess water, it is noticeable on some athletes whose face resembles an inflated ball , And the eyes are quite consistent with those of a resident of China).
  • 3. Suppression of excess blood pressure, is the consequence of the second paragraph. An increase in the fluid content due to a high level of estradiol leads to an increase in blood pressure, while the consumption of IA can reduce the level of estradiol, and therefore reduce the manifestations of hypertension.
  • 4. Reduction of the effect of high estradiol on the axis of the GGN, and therefore prevention of the problems of recovery of endogenous (native testosterone buy letrozole online) after the steroid intake cycle.
  • 5. Increased levels of endogenous testosterone in the body. This effect of aromatase inhibitors is based on the principle of feedback - suppression of estrogens below the normal level in the body signals the hypothalamus and pituitary about the need to increase this level to normal values ​​(the body always tends to balance), but the male body does not produce estrogens, it does not have ovaries, therefore The brain begins to produce gonadoliberin and then LH and FSH to increase the level of endogenous testosterone, which will later be converted into estrogen under the influence of the aromatase enzyme. But the AI ​​blocks aromatase, which means that the testosterone does not transgress to estradiol and estrone, so we can observe a vicious circle - an increase in the level of testosterone with the goal of turning it into female sex hormones, but since there is no necessary enzyme, then the estrogen level does not increase , And the brain has nothing left to stimulate the production of new androgen portions even more.

When planning the AC reception cycle, it is necessary to understand that not all steroids are susceptible to aromatization, so the intake of an IA can not always be justified. For example, steroid-susceptible aromatase enzymes include: all testosterone esters, boldenone (several times less testosterone, but still), methyltestosterone, to some extent fluoxymesterone.

The approach to the consumption of aromatase inhibitors on the course of steroids can be different, in general, there are three approaches: a. Expectation of signs of high levels of estrogen (signs of gynecomastia, water accumulation, hypertension) and subsequent use of IA to suppress side effects. b. The choice of the average dosage of IA and its intake every other day, to prevent the increase in the level of female sex hormones. at. Testing for the level of estradiol on the AC course (after about 2 weeks with the consumption of short-lived drugs or 4-5 weeks after the use of long-lived drugs), the administration of a dose of aromatase inhibitors, and the re-delivery of a blood test for estradiol to clarify the dosage of IA.

Seldom used drugs of the IA class include Aminglutemide (the first IA, suppresses not only aromatase, but also endogenous glucocorticoids and thyroid hormones) and Vorozol (similar to the action with buy letrozole online, which will be discussed below). In everyday life they often equate Mesterolon (also Proviron) with inhibitors, but it does not belong to the class of aromatase inhibitors, it is an androgen with some antiestrogenic activity, whereby it both "binds" aromatase and blocks the receptors of estrogen receptors, it should be noted that this The drug has significantly weaker anti-estrogenic activity than real IA, and too sensitive to female sex hormones, athletes can feel the side effects of increased levels of estrogen, even when pr Ieme Mesterolona on the course of the AU.

Like all medicines, aromatase inhibitor drugs have a number of side effects: nausea, vomiting, pain in the stomach, vomiting, fatigue, insomnia, constipation, excessive sweating, increased levels of "bad cholesterol" - LDL. Consider the most commonly used IA in the practice of bodybuilding: Letrozole. Created, like all preparations of its class, for the treatment of cancer associated with the sensitivity of tumor tissues to the level of estrogens (mainly breast cancer in women). The essence of his work is the target binding of aromatase, which leads to the lack of the possibility of binding the enzyme to androgens, disrupting the mechanism of estrogen level growth. The effectiveness of binding the drug with aromatase (at 2.5 mg per day) is 95%, which shows quite effective work of the drug. A very important feature of buy letrozole online in the treatment of cancer in women is the absence of increased levels of luteinizing and follicle-stimulating hormones, which excludes the possibility of signs of virilization. However, in men the situation is opposite and there is an increase in the level of endogenous testosterone. It should be noted that there is no correlation between the intake of Letrozole and changes in the activity of the thyroid gland, as well as its absence in the occurrence of strokes and heart attacks, which indicates the potential use of the drug by patients with cardiovascular disorders.

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