Formula: C18H24O2, chemical name: [(17beta) -Estra-1,3,5 (10) -triene-3,17-diol. Pharmacological group: antitumor agents / antitumor hormones and hormone antagonists; Hormones and their antagonists / estrogens, gestagens; Their homologues and antagonists. Pharmacological action: estrogenic. Buy estradiol online over the counter.
Estradiol 1mg pills over the counter penetrates by diffusion into the target cell, is transported to the nucleus of the cell, where it forms a receptor-ligand complex, binding to specific estrogen receptors. Estrogen receptors are found in various tissues and organs, they are found most in the female genitalia, especially in the vagina, uterus and ovaries, as well as in the pituitary gland, mammary glands, hypothalamus, bones, and liver. The ligand-receptor complex initiates the release of growth factors and cytokines and the production of i-RNA and protein by interacting with specific intracellular proteins and the estrogen-effector elements of the genome. Estradiol 1mg without prescription has a feminizing effect on the body, stimulates the development of the uterus, vagina, fallopian tubes, ducts and mammary glands, pigmentation in the genital area and nipples, the formation of secondary sex characteristics by female type, the closure and growth of epiphyses of long tubular bones. Buy estradiol online 1mg promotes regular bleeding and timely rejection of the endometrium, at high concentrations inhibits bone resorption, causes endometrial hyperplasia, induces the formation of fibrinogen and a number of transport proteins (thyroxine-binding globulin, transcortin, transferrin, sex hormone binding protein). Buy estradiol online over increases the content of iron, thyroxine, copper and other substances in the blood; Has a pro-coagulant effect, increases the formation of vitamin K-dependent clotting factors in the liver (2, 7, 9, 10), reduces antithrombin 3. Estradiol 1mg cheap price has antiatherosclerotic activity, reduces cholesterol and LDL (increases triglyceride levels), increases HDL; Modulates sympathetic regulation of smooth muscle tone and receptors to progesterone, converts intravascular fluid into tissues and causes compensatory retention of water and sodium; Prevents the degradation of endogenous catecholamines when taking large doses. Estradiol pills has the ability for mielodepression, which is associated with radiation damage, to accelerate the recovery of the level of leukocytes (neutrophils).
When administered orally, estradiol is fully and rapidly absorbed (bioavailability is approximately 100%). During the "first passage" through the liver, buy estradiol online over is metabolized to less active products - estriol and estrone. Estradiol almost completely binds to plasma proteins. Metabolites of estradiol with bile are secreted into the lumen of the small intestine, where they are reabsorbed (enterohepatic circulation). The final loss of activity of the drug occurs in the liver as a result of oxidation. Products resulting from biodegradation of estrce 2mg price are mainly excreted by the kidneys in the form of glucuronides and sulfates; In addition, small amounts of estradiol, estriol and estrone are found in the urine. With the application of TDTC, estradiol is released from the patch and enters through the skin into the bloodstream at the same rate, maintaining the necessary content of the hormone in the blood. When used as a patch and gel, estradiol pills does not undergo the "first pass" effect through the liver, so the variations in estrogen content in the plasma are much less pronounced than when using estrogens inwards. With the weekly application of TDCT, it is possible to achieve an estradiol 1mg tablets online plasma concentration similar to that produced during the reproductive period of life in the early follicular phase, with a plasma estrace tablets / estrone ratio of about 1. The absolute value of the plasma content of estradiol is directly proportional to the surface area of the patch. The average equilibrium concentration of estradiol tablets in plasma is approximately 40 pg / ml (with a plaster area of 12.5 cm2) and about 80 pg / ml (with a plaster area of 12.5 cm2). One day after the removal of TDTC, the plasma levels of buy estradiol online and estrone decrease to the original value. When applying the patch, the levels of conjugates of estrace generic cheap in urine increase 5 to 10 times and become initial within 2 days after removal of the patch. With the application of estradiol tablets in the form of a gel, the drug penetrates through the skin, while the greater part immediately enters the systemic circulation, while the part is retained in the subcutaneous fat and gradually discharged into the bloodstream. Bioavailability is 82%, the maximum concentration is achieved in 3-4 hours. When using the gel and patch-TTCT, excretion and metabolism correspond to excretion and metabolism of natural estrogens; In the body does not cumulate.
Estrogen deficiency in surgical menopause and in the climacteric period (including after radiation castration, ovariectomy); Secondary and primary hypomenorrhoea, amenorrhea, dysmenorrhea, oligomenorrhoea, alopecia with hyperandrogenia estrogen without a prescription, secondary estrogen insufficiency; Vaginitis (in old age and in girls), hirsutism in the syndrome of polycystic ovaries, infertility, hypogenitalism, weakness of labor, for suppressing lactation, endured pregnancy, viril hypertrichosis in women; Carcinoma of the prostate (palliative treatment), breast cancer in men and women with metastases (palliative treatment), prevention of postmenopausal osteoporosis in women, urogenital disorders (atrophic vulvovaginitis, dyspareunia, trigonitis, urethritis); As a means for stimulating hemopoiesis in men with acute radiation damage.
Duration of treatment and dose set individually. Admission of estradiol 1mg cost inside (with a small amount of liquid and not chewing, preferably at the same time of day): secondary and primary estrogen deficiency - once a day 2 mg, daily without interruptions; Therapy of postmenopausal women or women with a deleted uterus can begin any day, with the saved menstrual cycle, the first pill is taken on the 5th day of the menstrual cycle; The duration of therapy is 6 months, then a survey is conducted to determine the necessity and feasibility of continuing estrogen replacement therapy. The use of estradiol 0.5 mg is topical: once a day, apply the gel to the skin on the lower part of the anterior wall of the abdomen, or alternately to the left or right buttock; The initial dose is 1 g of gel (1 mg of estrogen tablets price); The average dose is 0.5-1.5 g of gel per day; The area of application is 1-2 hands estrace cost; The plaster is attached once a week; Therapy is carried out by 3-week courses with a break of 1 week or continuously; Each month for 10-12 days in the presence of the uterus jointly take progesterone. Intranasal use: once a day; The daily dose depends on individual characteristics and usually varies from 150 to 600 mcg, the initial dose is 300 mcg / day, during treatment it is necessary to select the minimum effective dose; Depending on the therapeutic effects, the dose is increased or decreased. Use intramuscularly: 1 time in 3-5 days 0.1% solution in oil 1 ml each. Prior to the use of buy estradiol online requires a complete general medical and gynecological examination, including the study of pelvic organs and abdominal cavity, mammary glands, cytological analysis of the endometrium, measurement of blood pressure; It is also necessary to exclude pregnancy. With prolonged treatment, this examination should be carried out every 0.5 to 1 year.
In the period of prolonged immobilization and 4-6 weeks before the planned surgical operation, it is recommended to interrupt therapy to avoid thrombosis. The drug should be stopped immediately with deep vein thrombosis, thromboembolic diseases, a significant increase in blood pressure, migraine-like headache, jaundice, sudden visual impairment buy estrogen online. With hormone replacement therapy, patients who suffer from hypertension need regular monitoring of blood pressure. At the beginning of treatment, patients with diabetes should be carefully monitored because of the possible decrease in glucose tolerance. The change in the content of estrogen in the blood can affect the analysis of some estradiol without prescription liver and endocrine functions. Estrogens can detain fluid in the body, so patients with impaired renal or cardiac function require careful monitoring. It is necessary to inform the attending physician about the joint administration of phenylbutazone buy estrace online, rifampicin, barbiturates, hydantoins, the appearance of unpleasant sensations in the epigastric region, unusually abundant bleeding or irregular where to buy estrogen bleeding in the period between application of the drug. When irregular uterine bleeding occurs, a cytological analysis of the endometrium is necessary. In therapy, it should buy estrogen patch online be borne in mind that prolonged intake of only estrogen in the menopausal period can lead to the development of endometrial hyperplasia and increases the likelihood of developing endometrial cancer. To reduce the likelihood of developing endometrial cancer, an additional progestogen is needed, which leads the uterine mucosa into the secretory phase, with its rejection and further menstrual bleeding after discontinuing progestogen administration.
With the development of irregular menstrual flow (in women with an intact uterus) against the background of buy estradiol online therapy to exclude malignant neoplasm of the uterus, diagnostic scraping is necessary. Postmenopausal women who have been on hormonal replacement therapy for a long time are at increased risk of developing breast cancer. With therapy for more than 5 years, you must carefully weigh the positive effects of therapy with adverse effects. In patients who are on long-term therapy, regular examination of the mammary glands is necessary, and it is also necessary to train them in regular self-examination. One should be especially careful when prescribing estrogens to women who have or generic estrogen have had fibro-cystic or nodular changes in the mammary glands in the past; In these cases, regular mammography and close monitoring are necessary. For women who take estrogenic drugs during the menopausal period, there is an increased risk of developing gallstone disease. Buy estradiol online does not restore fertility and is not a contraceptive. Do not place the patch on the waist or mammary glands. With the correct application of the patch, you can take a shower or a bath, but you should consider the possibility of peeling off the patch in hot water estrace price. Avoid getting the gel on the mucous membranes of the vagina and vulva and mammary glands.
Hypersensitivity, liver tumors (including history), estrogen-dependent neoplastic processes or suspected, sickle cell anemia, otosclerosis, herpes, angiopathy or retinopathy, persistent itching or cholestatic jaundice, history of gallbladder disease, undiagnosed or unusual uterine or Genital bleeding, thromboembolic states or thrombophlebitis in the active phase (other than prostate or breast cancer), thrombosis, thrombophlebitis, or thromboembolic events Oi, which are associated with taking estrogens (in the anamnesis); Hypercalcemia buy estrogen otc, which is associated with bone metastases of breast cancer; Inflammatory diseases of female genital organs (endometritis, salpingo-oophoritis). Only for the treatment estrace 1mg of prostate and mammary gland cancer (in addition): diseases of the heart or brain vessels, thromboembolic diseases or active thrombophlebitis (high doses of estrogens, which are used for therapy, increase the likelihood of myocardial infarction, thrombophlebitis, pulmonary embolism).
Bronchial asthma, migraine, diabetes mellitus, epilepsy, heart failure, arterial hypertension, coronary heart disease, renal failure, chronic or acute liver diseases (including history) with changes in functional hepatic samples, edematous syndrome, hyperlipoproteinemia, endometriosis, porphyria, Fibrocystic mastopathy, pituitary tumors, Rotor or Dubin-Johnson syndrome, diffuse connective tissue diseases.
Contraindicated during pregnancy, including and presumed (since estrogen embryotoxic action may have) use of estrace pills no prescription required. During the research, the connection of congenital malformations with the use of some estrogens during pregnancy was shown. For the duration of buy estradiol online therapy, breastfeeding should be stopped (estrogens are excreted in breast milk).
Genitourinary system: in women - uterine bleeding of unknown origin, bleeding "breakthrough", spotting and changing the character of uterine bleeding, premenstrual syndrome, metrorrhagia (a sign of overdose of estrogen tablets without prescription), dysmenorrhea, amenorrhea, increased size of leiomyoma or uterine fibroids, alteration of cervical secretion, vaginal Candidiasis, changes in the nature of vaginal discharge, endometrial hyperplasia (when used without progestogen), symptoms of cystitis (without bacterial infection), endocervical carcinoma Metry (in menopause in women with an intact uterus), with continued use - sclerosis of the ovaries, increased libido, sensitivity, tenderness and increased size of the mammary glands; In men - sensitivity and soreness of the mammary glands, decreased libido, gynecomastia.
Other: lowering of tolerance to carbohydrates, change in body weight, spasms of gastrocnemius muscles, worsening of porphyria; With prolonged use - a violation of the exchange of calcium, sodium and water with the formation of peripheral edema.
Estradiol reduces the activity of anticoagulants, diuretics, hypoglycemic and hypotensive drugs. Estradiol increases the effectiveness of lipid-lowering agents. Buy estradiol online lowers glucose tolerance (you may need to adjust the dosage regimen for hypoglycemic drugs). Inducers of microsomal liver enzymes (eg, anticonvulsant and antimicrobial agents) can accelerate the metabolism of estrace pills order online, increase the clearance of sex hormones and reduce their clinical effectiveness. Significant consumption of alcohol during therapy can lead to an increase in the content of circulating non prescription estradiol. Drugs of the thyroid gland and folic acid strengthen the action of estradiol.
When an overdose of buy estradiol online develops nausea, vomiting, and sometimes - metrorrhagia. It is necessary: drug withdrawal, maintenance and symptomatic treatment.