Characteristics of substance Anastrozole for sale: Antitumor agent, selective non-steroidal aromatase inhibitor. White crystalline powder. Solubility in water 0.25 mg / ml (at 25 ° C), does not depend on pH in the physiological range arimidex for sale online. Very easily soluble in methanol, ethanol, acetone, tetrahydrofuran. Easily soluble in acetonitrile. Buy anastrozole online. Molecular weight 293.4.
Pharmacological action - antitumor, inhibitory synthesis of estrogens.
It is active against estrogen-dependent where to buy arimidex over the counter breast tumors in postmenopausal women. Androstenedione anastrozole price - the main source of circulating estrogens in postmenopausal women, in peripheral arimidex tablets no prescription need tissues is converted to estrone, and then to estradiol, this process takes place with the participation of the aromatase enzyme. The mechanism of action of arimidex for sale online otc is associated with the inhibition of aromatase (a selective non-steroidal inhibitor) in peripheral tissues, incl. Fatty, which leads to a decrease arimidex cost online in the amount of estradiol. When anastrozole 1 mg is treated at the recommended dose of 1 mg per day, the level of estradiol is reduced by 70% within 24 hours, by 80% after 14 days. Suppression of serum estradiol levels is maintained for 6 days after discontinuation of daily intake of 1 g of buy arimidex online. A decrease in the level of circulating estradiol has a therapeutic effect in breast tumors in postmenopausal women. With daily intake of doses of 3, 5 and 10 mg, anastrozole 1 mg had no effect on the secretion of cortisol and aldosterone. Arimidex for sale online did not show direct progestogen, androgenic and estrogenic activity in animals, but it altered the levels of circulating progesterone, androgens and estrogens.
After oral intake of 83-85% of the dose, eating influences absorption (reduces absorption). Cmax is achieved after 2 hours (on an empty stomach). In blood with plasma proteins, up to 40% is associated. The equilibrium concentration in the blood with daily intake is reached after about 7 days, its value is 3-4 times higher than with a single admission. Anastrozole price over the counter is extensively metabolized in postmenopausal women, less than 10% is excreted unchanged for 72 hours after ingestion, 60% is excreted as metabolites. Biotransformation in the liver is carried out by N-dealkylation, hydroxylation and glucuronization with the formation of inactive metabolites, the main one of which is triazole arimidex pills. Terminal T1 / 2 is approximately 50 hours. The pharmacokinetics of anastrozole price does not depend on the age of women in the range of 50-80 years.
Acute toxicity in animals. In studies of acute toxicity in rodents (rats), it was shown that with a single oral dose, the lethal dose of buy arimidex without prescription exceeded 100 mg / kg / day (approximately 800 times the recommended dose for a person, in mg / m2) and was associated with severe gastric irritation (necrosis , Gastritis, ulceration, hemorrhage). When administered orally to dogs, the median lethal dose exceeded 45 mg / kg / day.
Mutagenicity. Anastrozole 1 mg for sale otc did not exhibit mutagenic and clastogenic properties in a number of in vitro and in vivo tests, including. In the Ames test, a test for chromosome aberrations on human lymphocytes, in a micronuclear test in rats.
Reproductive Toxicology. Oral administration of generic arimidex for sale online to female rats (from the time of 2 weeks before crossing to 7th day of pregnancy) caused a significant increase in infertility and a decrease in the number of safe pregnancies at a dose of 1 mg / kg / day (about 10 times the MPDR in mg / m2 and 9 times Exceeds AUC0-24 of postmenopausal female volunteers when taken in the recommended doses). At doses ≥0.02 mg / kg / day (about 1/5 of the MPDCH in mg / m2), preimplantation loss of eggs or fetal loss was noted. After a 3-week course, recovery of fertility was observed 5 weeks after drug withdrawal. It is not known whether the noted effects of impaired fertility in rats indicate the possibility of impaired fertility in humans. Carcinogenicity. Two-year studies in rats when administered orally to buy arimidex price cheap animals at doses of 1.0 to 25 mg / kg / day (10-243 times the MDM in mg / m2) revealed an increase in the incidence of hepatocellular adenoma and carcinoma, as well as stromal uterine polyps in females , Adenomas of the thyroid gland in males when the drug is administered in high doses (25 mg / kg / day). There was a dose-related increase in the incidence of ovarian and uterine hyperplasia in females. At a dose of 25 mg / kg / day, the plasma levels of AUC0-24 in rats were 110-125 times higher than those in postmenopausal women with therapeutic doses of drugs.
In two-year studies, an increase in the incidence of benign tumors (stromal, epithelial, granular) ovaries was observed in mice with oral administration of anastrozole cost without insurance at doses of 5 to 50 mg / kg / day (approximately 24-243 times the MPD in mg / m2) at all Studied doses. Dose-dependent ovarian hyperplasia in female mice was also noted. These changes in the ovaries are regarded as a specific consequence of the inhibition of aromatase in the body of rodents and are not considered clinically significant for humans. The frequency of detection of lymphosarcomas was increased in females and male mice at high doses. At a dose of 50 mg / kg / day, the plasma levels of AUC0-24 in mice were 35-40 times higher than those of postmenopausal female volunteers when taking drugs at therapeutic doses.
Adjuvant therapy of early hormone-positive breast cancer in postmenopausal women, treatment of advanced breast cancer in postmenopausal women, adjuvant therapy of early hormone-positive breast cancer in postmenopausal women after tamoxifen therapy for 2-3 years.
Hypersensitivity, pre-menopausal period, concomitant therapy with tamoxifen or preparations containing estrogens; Expressed renal failure (creatinine clearance 20 ml / min), moderate or severe hepatic insufficiency (efficacy and safety not established), pregnancy, breast-feeding.
Osteoporosis, hypercholesterolemia, ischemic heart disease.
The action category for fetus by FDA is X.
Preparations containing estrogens reduce the pharmacological action of arimidex for sale online, and therefore they should not be administered simultaneously with anastrozole 1 mg. Do not prescribe tamoxifen at the same time as anastrozole for sale, since it can weaken the pharmacological action of the latter. In the joint use of anastrozole and tamoxifen in patients with breast cancer, the plasma concentration of where can i buy arimidex buy was reduced by 27% compared to that with anastrozole over the counter alone, and the combined administration did not affect the pharmacokinetics of tamoxifen and N-desmethyltamoxifen.
There was no clinically significant effect of anastrozole on the pharmacokinetics and anticoagulant activity of warfarin. In a study in 16 male volunteers, anastrozole had no effect on exposure (estimated by Cmax and AUC) and anticoagulant activity (measured by PV, APTT and thrombin time) of warfarin.
Single clinical cases of anastrozole overdose are described. A single dose that could lead to life threatening symptoms has not been established. Treatment: induction of vomiting (if the patient is conscious), symptomatic therapy, monitoring the patient and monitoring vital organs and systems. Dialysis is possible. A specific antidote was not found.
In women with a receptor-negative tumor to estrogens, the efficacy of anastrozole has not been demonstrated, except in cases where there was a previous positive clinical response to tamoxifen. The efficacy and safety of arimidex for sale online and tamoxifen in their simultaneous application, regardless of the status of the hormonal receptors, are comparable to those of a single tamoxifen (the exact mechanism of this phenomenon is not yet known).
In case of doubt in the hormonal status of the patient, menopause should be confirmed by the determination of sex hormones in the blood serum. In the case of persisting uterine bleeding against the background of taking anastrozole, consultation and supervision of the gynecologist is necessary. Preparations containing estrogens should not be administered concomitantly with anastrozole for sale. These drugs will level out its pharmacological action. Reducing the level of circulating estradiol, anastrozole can cause a decrease in bone mineral density. In patients who have osteoporosis or who are at risk for developing osteoporosis, bone mineral density should be assessed by densitometry (for example, DEXA scans) at the beginning of treatment and in dynamics. If necessary, treatment or prevention of osteoporosis should be initiated under the close supervision of a physician.
There is no data on the simultaneous use of anastrozole 1 mg and analogues of LHRH (releasing hormone luteinizing hormone). It is not known whether anastrozole improves the results of treatment when combined with chemotherapy.
Some of the side effects of arimidex for sale online, such as asthenia and drowsiness, can adversely affect the ability to perform potentially dangerous activities that require increased concentration and speed of psychomotor reactions. In this regard, it is recommended that when these symptoms occur, use caution when operating vehicles and mechanisms. Anastrozole was developed by Zeneca Pharmaceuticals, and at the end of 1995 it was approved for use in the US. The drug was developed as a new agent for the treatment of operable breast cancer in women, for which earlier, for a long time, the drug Tamoxifen was used. To move away from the established trends, there were essential reasons. Shortly after its market launch, buy arimidex was included in an extremely large-scale, multicenter, double-blind study based in Rome. The study evaluated the use of arimidex for sale online and Tamoxifen, alone or in combination, in 9,366 postmenopausal women after breast cancer surgery. The results demonstrate a significant advantage of buy arimidex online in comparison with Tamoxifen. As a result of treatment, patients showed regression of the disease and overall survival rates improved. After the publication of the study in 2002, Anastrozole became known as a new drug for additional treatment of breast cancer in postmenopausal women. Approximately at the same time the drug also becomes popular in men (bodybuilders and athletes), because the drug causes a strong suppression of estrogen.
The synthesis begins with the nucleophilic substitution of two benzyl bromides in a, a-dibromo-isotylene (obtained by radical bromination of mesitylene) with cyanide by treatment with potassium cyanide under phase transfer conditions to form dinitrile. Exhaustive methylation with methyl iodide and sodium hydride results in the replacement of the more acid side chain of hydrogen atoms by methyl groups. The use of bromine in the presence of benzoyl peroxide leads to the formation of the corresponding benzyl bromide. The reaction of this 1,2,4-triazole in the presence of a base completes the synthesis of the aromatase inhibitor.
Athletes using steroids use anastrozole 1 mg in order to minimize the side effects associated with the increase in estrogen levels often observed with anabolic / androgenic steroids. Compared with traditional drugs, such as Nolvadex and Proviron, arimidex for sale online without prescription is much more effective in controlling estrogen levels.
The ATAC trial (Arimidex, Tamoxifen, individually or in combination) is an international randomized controlled trial of 9,366 women with localized breast cancer who took either Anastrozole or Tamoxifen or both drugs for five years at a time, followed by a five-year follow-up. After more than 5 years of study, patients from the group whose members received Anastrozole showed significant improvement in clinical outcomes, compared with patients in the Tamoxifen group. Researchers believe that Anastrozole is more preferred as a drug therapy in postmenopausal women with a localized estrogen receptor (ER) positive breast cancer. Another study showed that with the administration of Anastrozole, the risk of recurrence was reduced by 40%, but the risk of bone fractures increased. The study concludes that ER-positive patients who received a 2-year treatment with Tamoxifen had the benefit of switching from tamoxifen to arimidex cost.
Anastrozole can be used not for the intended purpose in children with premature puberty, or in children with pubertal gynecomastia. After the onset of puberty, the epiphyseal plate begins to close due to increased production of estrogen, which avoids local metabolism and spreads through the circulatory system. Arimidex for sale online can help slow this process, and also increase predicted adult growth in young men taking protein-based peptide hormones for the treatment of growth hormone deficiency.